Seroquel XR (I take the extended release) has been my favorite antipsychotic yet and I have tried about 10 different ones over the years. Seroquel XR helps calm my manias and I believe is also helpful at keeping depression and anxiety in check for me. It is a good sleep aid and usually has a lower chance of causing people EPS (i.e. akathisia, Tardive Dyskinesia, dystonia) or elevated prolactin levels than other antipsychotics. That has been my experience.

Seroquel can be initially very sedating, but if it is, that usually eases for most people over time. It eased for me. Many complain about weight gain on Seroquel. That's common, but not that bad for some. For me, my Seroquel XR can be weight neutral up to 600 mg sometimes. I'm currently taking 700 mg. I'm hungrier than before, but the increase helped what it was supposed to help.

I've taken regular Seroquel at various doses in the past. I thought it was helpful, but prefer the extended release.