I don't really know anything about this. But I noticed no one had yet replied to your post. So I thought I would. I was on Effexor twice. And it actually made me suicidal. I can't take it. So just based on my own personal experience I'd have to say, at least for me, Effexor would probably be unlikely to fuel my anxiety. It would be more likely to make me even more despondent than I already am. But of course, as we all know, different people react differently to different medications. So it may be that the best you can do is to monitor your reaction to your increased dosage & keep in touch with your prescriber. Perhaps other PC members will yet have other perspectives they can share. Best wishes...