I can't have antidepressants as they have induced mania before. Seroquel actually is indicated for and licensed for use in treating bipolar depression and at the right dosage has been effective for me. To found reference to studies that showed it was more effective than placebo with absolutely no risk of induced mania. I wouldn't think there is any harm in trying a dosage increase first before potentially adding another medication into the mix. I REALLY WANTED to when I was unwell. They would NOT give me antidepressants because they said it would induce mania again or even worse mixed state [emoji2372] so I trusted my team. And im glad I did as I've definitely improved massively.