I agree. I saw a study once where animal subjects suffered something like a 6% reduction in brain mass over the course of 18 months from high-rise quetiapine. Scary. I've been on it for 8yrs, and was on 1000mg a day at one point. I definitely feel like my general mental abilities are fading. I've tried coming off it and other meds a heap of times, but I end up not sleeping and go downhill fast. Sometimes I end up in a psych ward which is the last place I want to be.