I've never been depressed, but my husband has dealt with depression for many years. Face it, when you feel like crap about yourself, why WOULD you feel like having sex? I completely understood why our sex life was almost nonexistent for a while when he was at rock bottom. I was grateful that he would let me hold him. It killed me to see him alienate himself to the extent he did, but I could still understand it and never dreamed of pushing the sex issue. Now that he's better and on SSRIs (Lexapro), his libido is just like it was when I first met him, so I can say that I have noticed NO side effects in that area. He's 30, for some perspective. I started on Lexapro myself and I think my libido has actually improved somewhat, but for different reasons. One, I feel much better about myself in terms of my body image -- I haven't lost any weight, but I don't see myself as being as fat as I had thought I was. Two, I used to not make time for sex because I was always overbooking myself and running around like a maniac trying to cram as much into one day as possible. Having sex felt like it was taking away from my productive time. The Lexapro has slowed me down quite a bit, in a GOOD way, and I'm doing a much better job at prioritizing what's important in my life.