Oh - I forgot to mention that I got manic on the SSRI's, too. Even with bipolar meds (Lamictal, for example) I had weird reactions to SSRI's.
I have been taking Pristiq for almost 2 years (along with my other meds). I find the Pristiq really helpful for depression, and it doesn't set off mania.
Anyway, how's it going with the Cymbalta?