wildflowerchild25, I share falcon09's experience that Seroquel XR is less sedating than the iR was. I'll share this, too. Though it can't be certain that everyone will react the same to the same medications, for me, Seroquel XR is a medication that started out extremely sedating, but the sedation eased over time. If you are working, and the sedation flat out prevents you from doing your job, then I fully understand the extreme frustration and how it can be a "no-go". However, if you are in a position to "ride it out" a little bit, you might find yourself happy if you have some patience while you adjust to the medication. Patience is something I had almost none of in my youth. In fact, my mother used to harass me saying over and over again "Patience is a virtue. Patience is a virtue. Patience is a virtue." But I had to learn it, eventually. My bipolar disorder experience gave me no choice. Patience in adjusting to medications and their side effects. Patience waiting for depression to lift. Patience for all kinds of things! It sucks, but that's life sometimes. I am extremely happy I gave Seroquel XR a fair chance. I've had other medications that I felt similarly about. For example, when I first started taking Geodon, in the past, it knocked me out cold. But then, over time, it didn't even sedate me enough. Seroquel XR still works great for me, with little sedation when it shouldn't sedate, and adequate sedation when it should (nighttime). Though I do believe Seroquel XR contributes to my high cholesterol and sometimes high triglycerides, it hasn't given me any other side effect. I generally even consider it weight neutral to only mildly challenging, in that respect. Other antipsychotics, for me, were far far less tolerable.