Long-running mixed episodes are the worst. In the past I have had episodes that have lasted over a year, and then came back again after a short break. In fact, I was pretty much in a near constant mixed episode for over nine years until March 2019. I totally understand how hopeless it feels, but I urge you to hang on and keep trying new options. What stopped my mixed episodes was Ziprasidone (Geodon). I had tried dozens of combinations of meds to no avail until I was given Ziprasidone. That was my wonder-drug. There may very well be one, or a combo, for you out there. It helps to have a pdoc you trust who you can work with closely to find the right fit. Changing meds too often can send us off balance, but it is also pointless staying on meds that aren't working. My heart goes out to you as mixed states are pure hell. Stay in treatment and don't give up. There is hope.