I take 700 mg of the extended release version (Seroquel XR). 50 mg in the morning and the remaining 650 mg at night. The only concerning side effects I have are high cholesterol and occasionally high triglycerides. If I eat a lot of sugar for a while, I can sometimes reach pre-diabetic, but if I'm more reasonable, I'm usually OK, in that respect. But we're all different in terms of vulnerability to this. For the most part, my Seroquel XR is weight neutral. Sometimes with dose increases, I do get a bit of extra hunger for a bit. I am a bit overweight, but likely no more than I might be even if I never took bipolar medications. I will say that it is a challenge to lose the weight. If I could, I'd hope my cholesterol and triglycerides would normalize.