I said 6 to 10, but it is an estimate. My bp 1 was clearly childhood onset, but the first depressive episode was not until age 17. Had another one at 23, another at 28, and another at 41. Some others. By far the worst series of them was from ages 41-44, with a couple of very dangerous S attempts. It is literally a miracle that I am alive. Literally, a miracle.

Mine have lasted different lengths of time, but some have been as long as maybe a year or so. They can be quite treatment-resistant and I have been on maybe 30 antidepressants of various types over the years. Virtually none have helped. I personally believe our current and past strategies for developing antidepressants is totally off target. Just an opinion, but I think we are missing the molecular basis for many, many patients' depression by being focused on sserotonin so much, which, in my opinion, is not the primary driver of most depression in humans. I believe the future is in glutamate/NMDA receptor research. I think this is why ketamine and other related compounds are/is so miraculous for some patients. Just an opinion, though.

I agree that the memory of my pain somewhat fades with time, which is n o doubt, a protective mechanism. But when it is bad, it is truly life-threatening.