bpcyclist, the sciences were always my weakest subjects, but I've grown more interested in them in my middle-age. What I do know is that it is curious how within the bipolar community, you see that medications that are "miracle meds" for some, are downright horrible for others. I wish I could discuss this more intelligently, but despite my limitations, I think the "bipolar spectrum" idea is significant. That we have "different flavors" of bipolar disorder, as my psychiatrist says. Maybe we even have slightly different disorders, in some cases, beyond just bipolar 1 vs. bipolar 2, etc.