Zoloft had to be the worst. My pdoc thought it wouldn't make me manic, because I was on a mood stabilizer with it, but she ended up being wrong. In fact, it thew me into a mixed episode with paranoia. No more SSRI's for me.

Seroquel at a moderate dose isn't bad for me, but it was pretty terrible on a high dose. I had low BP, problems breathing at times, felt like I was going to pass out in the morning, twitching. Terrible. It's amazing what a difference the change in the dosage makes though for me.