For me agitation is indicative of one of two things: a medication side effect or a mania.

Amped up anger/rage that feels uncontrollable is most likely (for me) mania, dysphoric mania - or it's a reaction to a major trigger that sends me over the edge. For example, one day I was having a really rough time due to a certain anniversary. My therapist forgot about that anniversary, ran overtime in a meeting, and called me in 15 minutes late. I was like a tiger trapped in a cage. Pure raging fury, and I couldn't calm myself down until my therapist literally sat next to me, held me, and I fell apart, crying.

What helps? Without any doubt (for me), medication. In addition, I am learning more techniques in therapy for anger management. For example, I am really looking at how my rage affects other people...learning that I need to have compassion for whoever is the target of my fury.

Breath work is extremely helpful.

I'm motivated to strive to make my anger a "normal" anger, because I have lost dear people in my life due to me going off on them. The loss and shame is just plain not worth it anymore. I want to change.