Myself, being on anti-depressants for over 4 years now, have come to a couple conclusions:

1. Everyone is different. My best friend LOVED celexa. It did nothing for me & I hated it.

2. After a while, it seems the body sort of gets used to it, so you have to switch. I was on Effexor XR for the longest time & began to feel as if it wasn't working anymore. I consulted my doc & he switched me to Cymbalta (60 mg/day). I am still on Cymbalta and love it.

Now, I am not a doctor, but these are my own personal opinions.