Right now, I have no problem. I do think, in the past, depression has curbed my humor, especially if it's a paralyzed type depression. But even then, perhaps not all of the time. Sometimes the type of humor changes according to my mood.

Medications as a cause for reduced humor? I think that can definitely be so. Some medications (like Depakote) made me depressed, which therefore reduced my humor. I do remember being plenty jolly (and manic) at times on Lithium, but Lithium could also be like a dark cloud overhead or fog. In fact, as I gradually went off of Lithium, I felt such a cloud clear. That didn't mean depression lifted (there might not have been any), but sort of the feeling one gets on a crisp spring or fall morning, at a tent camp, when you can really BREATHE and the air is particularly clean and fills your lungs more. Like as if a tight belt is figuratively loosened around the brain and chest. Do you know what I mean?

I think there have been times when I mistook either sedation or cognitive dulling for a mild form of depression. Sure, mood elevation can help temporarily clear that, but so can medication reductions, sometimes. I can't count how many times my Seroquel XR dose has gone up and down, up and down, trying to find the perfect balance. Sometimes I find it and maintain it for a while, and do a the happy dance, but then the balance is lost again...and either up or down, or around. I do the Hokey Pokey and I turn myself around. That's what it's all about! YEAH!