I have my Seroquel XR adjusted up and down by 50 mg, frequently. Occasionally up 100 mg or even 150/200 mg, if my mood really skyrockets, which is rare. I don't mind the adjustments. It's not a biggie, for me.

I have had some periods when an evening dose of Seroquel XR alone (even 650 mg) seems to wear off too soon the next day. For that reason, my psychiatrist has added 50 mg Seroquel XR to my morning medication pile. That works well for me, but if/when I find myself tiring/dragging butt too early, my psychiatrist simply let's me remove the morning dose.

I don't know what dose you take per 24 hours, but sometimes smaller doses are more sedating than larger ones, as I believe sarahsweets sort of referenced.

My dose of Seroquel XR may be a bit larger than many people's. There's a possible drug interaction with my Tegretol that may require a bigger dose. I don't think you take Tegretol, so that likely doesn't apply to you.