I have wanted to post this for a long time. I have had the experience of having a number of my meidcations work very differently for me as time marches on. Usually, not as well. Sometimes, they start doing almost the opposite of their intended purpose. For example, some meds that used to make me manic occaisonally now, they will put me to sleep. Very reliably. Weird.

I don't know why this happens. Has my brain changed over time? Is my bipolar illness different now in some ways? I have no idea, but was wondering how others' experiences have been. I am sure I am not the only one. I suspect this is why I am always having to change my medication around or something.