I tend to think it is our brains. However I honestly can't say exactly why I feel that way, only that I know what my brain feels like when a med is working and when it has changed and isn't working anymore.

I never had an AD work for long until Emsam which my pdoc tells me rarely poops out. I don't know why but she just says that's been her experience and I'm nearing 11 years on it so it seems to be stable for me. Of course clozapine is also stable for me so maybe it's not my brain and is the drugs. I'll have to try to remember to ask her next time I have a chance.