@bpcyclist, have you ever been on Effexor? I was wondering because it really does the trick for me, at least in combination with all the other stuff I take, which includes Abilify. I take Remeron, Abilify, and Effexor, and it does the trick for my depression. Of course, this doesn't necessarily mean it would help you, too, and you said you've already been on Remeron, but I just thought I'd share my experience. I hope you find some relief from depression soon.