Seroquel caused a lot of weight gain but this was also before I had gastric bypass. I was metabolically changed by it. Many people think WLS is only to control hunger but the procedure I had in 07 actually changed my metabolism and the way I absorb food so it helped me a lot. I had to go back on them for the BP and was terrified but my doctor told me that Geodon was pretty weight neutral. I can say that has been the case for me. I have been on it like 13 years and have fluctuated with 20lbs back and forth which I think is normal after 13 years, and I need to exercise more for sure.