I've had (have) twitches and tremors. I think it's caused by a combination of Seroquel and lithium. I had tremors on lithium before I started Seroquel but it got worse after I started that. It seems to be worse after exercise. I've always drank almost exclusively water (just a habit, not fanaticism) and never alcohol or coffee, but since I'm on lithium and other meds I especially make it a point to abstain from those.