For me I don't notice much of an effect from the Lamictal. Maybe that's a good thing. I did notice an effect in the past with Lithium and Depakote. The Lamictal definitely did not help with my depression. Eventually I went on Latuda to help with the Bipolar Depression and it has worked wonders. I still take the Lamictal since I'm doing well and don't want to mess with what's working.