I'm with all the previous posters on this one. Everyone reacts differently to different meds so best for me may not be best for you.

However I'll share what I have experienced..

I am currently taking Prozac. I have been on it for several years now and have had no major side effects. My dose is 40mg. I can't say that it has had any profound effects but I also haven't had any problems either.

I took Cymbalta for a short time but discontinued because it caused my blood pressure to go up. Right now I am taking Effexor XR which is part of the same family as Cymbalta. Effexor has been a life saver for me.