Interestingly, I was at 300mg of Lamictal (when I started taking it about 2 years ago) and was still terribly depressed. I told my pdoc that I was done with it, and that I wanted ECT. She agreed to look into ECT for me, but asked if I'd try one antidepressant before committing to ECT. I perfunctorily agreed (thinking it would be a waste). She prescribed Pristiq and 10 days later I felt really good. No depression. I felt so lucky! So far, the Pristiq has been excellent (it's been 21 months).
I'm not sure why Pristiq is not prescribed more frequently, since it is indicated for bipolar depression.
With your depression as severe as it is, maybe trying an AD is worth it? I mean...yes...you might have a manic reaction to an AD, but it seems worth a try.
Are you feeling any benefit from the Lamictal yet? Obviously not a lessening of depression, but any other positives?
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