Back when I was on multiple med cocktails mixed with antidepressants often. Also back then I let the docs just drop and add meds Willy nilly without any time to get off the half-life of a med before starting a new one. Didn’t take but a small amount of stress to set me off. The last time I had a mixed episode the stupid clinic I was going to said trazadone was for sleep, but it’s an antidepressant and flipped me into an agitated mixed episode I almost lost it. Haven’t had a mixed episode in 5 years. No benzodiazepines, no antidepressants and low stress and a priority on sleep routine has worked wonders. I avoid all OTC 24 meds that can be activating