Ketamine can sometimes be effective in the treatment of depression, but it is also problematic. For the people that I've seen treated with it or its variants, the benefits seem short lived. I think that with any treatment, both medication and therapy are essential. I've actually seen better response to older generation antidepressants or ECT with regards to sustained benefit. That being said, I'm not a doctor and it's important to note that every person is different. Hopefully the medication and treatments are helpful for a lot of people. I think it's always good to have hope and to be willing to try things that may work to help alleviate the pain and struggles of depression.