Has anyone taken Trintellix for treatment resistant depression? I’ve failed three drugs in the SSRI class and two in the SNRI class. The only antidepressant I ever had success with was Effexor, but it eventually lost its efficacy. I recently took Cymbalta, which helped with my depression but made me so anxious and irritable that I couldn’t stay on it.
My psychiatrist mentioned Remeron and Trintellix, the latter of which I had never heard of. I’m interested in both medications because, from what I’ve read, they function differently than the SSRIs and SNRIs I haven’t had luck with. I’m leaning toward Trintellix because I’m not enthused about gaining weight with Remeron, but it’s so new that I don’t know anyone who’s taken it and I don’t see it mentioned much in forums. It seems to affect several different chemicals in the brain so I’m not sure if it’s classified as an SSRI, an SNRI, a mood stabilizer, or all three. It also appears to affect serotonin a bit differently than the regular SSRIs.
Anyway, I’d like to hear about people’s experience taking the drug.