It is definitely possible to return to work. I didn't work for over a decade. It was humiliating living on the Ontario Disability Support Program. I had enough of poverty and not having a purpose, so I decided to work part-time to ease myself back into the world. I did this, because I wanted to make sure I could cope and keep my job.
My job search was very specific. I made sure to look for work that fit my personality and strengths. Most service and entry level jobs are not appropriate for me, so I made sure to stay away from those. I found my place in manufacturing.
After working part-time for 3 years I decided to go to a community college in southwestern Ontario. The diploma program I was in offered optional paid co-op placements. After my 8 month placement I was offered full-time work at the same company.
Good luck.