I found this quote from the article you mentioned below very interesting:
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As our prosperity rises, our mental health is on the decline—and fast. Rates of depression, anxiety, suicide, addiction, and other psychological disorders have skyrocketed in recent years, and nobody knows what to do about it.
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Originally Posted by Xynesthesia2
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Psychedelics may be able to help individuals, but I think there is a larger social issue, too, related to what you said here:
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Originally Posted by Xynesthesia2
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There might be an inborn predisposition, but "nurture" might be able to adjust it somewhat, and then it's easier to build upon that with independent explorations? Conversely, if that was not established "from start" it may be much trickier to apply any external intervention... including psychedelics.
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For instance, what kinds of social factors affect the DMN, both developmentally and later, and how?