I was on 300mg of venlafaxine. I naturally have a fast metabolism. I was whippet thin before medication. My friend says I have the constitution of an ox to be able to tolerate seroquel. : D I know people who find anti depressants too sedating. I was on a combination of mirtazapine at night and venlafaxine in the morning.
I am now on sertraline instead of venlafaxine. The venlafaxine worked very well when I was on it which was about four years or so. Venlafaxine has a short half life making coming off it difficult. The doctors usually use cross titration to help people switch.
When halting venlafaxine I had strange pins and needles sensation in my legs and the brain zaps and some physical after effects like fatigue and sweating. Once the sertraline, which has a longer half life, built up and took effect I was ok and the withdrawal side effects faded.