Hi littlebagdog. I’ve never taken Esketamine. I tried once but my insurance wouldn’t approve it. After I relocated I found a doctor that did ketamine infusions at half the price of where I moved from. I had about 8 infusions then started the ketamine nasal spray made by a compounding pharmacy, which I’ve been on for about 10 months now. It’s not been a miracle drug but it’s given me a level of relief from depression that I haven’t experienced in years. My whole life began to change. I made plans, I had goals and I felt more emotionally resilient. I didn’t appreciate just how much it made a difference until I moved again and haven’t had a dose in over 2 weeks. That along with the stress of moving has me in a state of depression that I haven’t experienced in a long time. I’ve had worse but it’s been a long time since I had this lack of motivation and numbness that I feel now. I met with a new doctor that prescribes ketamine nasal spray and I will be getting my new prescription in the mail in the next few days. If there is any good that came out of this episode of depression it is that I have a new appreciation of how ketamine has changed my life. I will never take it for granted and I hope to get long term benefits from it. So having said all that, if your insurance will cover it I say go for it. Hopefully you will get some relief from depression and be able to live a better and more fulfilling life. If you find you can’t afford it there are doctors that will prescribe the nasal spray that some compounding pharmacies will make at a fraction of the cost is Esketamine. I wish you the best.