You certainly did a lot for your wife in terms of taking care of her and even donating one of your kidneys so she can get well and live longer. Yet, you don't own her and she is most likely very stiffled with how you have been hovering over her and constantly in her space. It's reasonable that your wife already felt very confined for a lot of years while he health problems limited her so much. The fact that you are constantly around and in her environment and she has not been able to go out due to Covid risks due to her vulnerablity, she is genuinely miserable.

I was thinking how even going out for a drive would help but then that would still mean you hovering. Does she have a drivers license so she can at least go for a drive herself and get a feeling of some freedom?