For me, my Seroquel XR is effective for many issues. Higher doses can curb my growing mania, but sometimes even growing depression, specifically mixed type. It's a good remedy for my anxiety and agitation which can amplify negative feelings and thoughts. Or, sometimes even just decreasing my Seroquel XR helps by alleviating excess fatigue. Fatigue, itself, can be a downer. Fatigue can make my thinking cloudy. By easing it, my thinking clears, and energy rises, which often brings a more pleasant mood.