Hi, this is Mogadore. I have depression but it has been controlled for nearly 20 years via Prozac. Unfortunately my sister has TRD and I am trying to support her but fear she is doing harm to her current program. I am looking forward to communicating with some friends here who have TRD or have a loved one with TRD. To be very honest...I love my sister, but sometime it is so very hard to like her when she is destructive. I really struggle with this. I look forward to talking with y'all!