So Sorry that things are being hard for you and your sister! You've Hopefully come to the right place for support as there are Hopefully other people whom are struggling with depression and perhaps even some whom are struggling with treatment resistant depression specifically. Is your sister currently seeing a therapist or pdoc to try to manage her depression as much as possible? If she isn't that may be worth considering. Feel free to write on this forum and to contact the admins and moderators in case you need assistance. i am also availabe if you need it and Hopefully others as well if you just ask. Please do not give up. You and your sister as well deserve much better. Try both your best. i Hope and Pray things will improve soon for you both. Find distractions and work out. Never give up Hope. Sending many Safe, warm hugs to BOTH you, @Mogadore, your Family, your Friends and ALL of your Loved Ones! Keep fighting and keep rocking NO MATTER WHAT HAPPENS, OK?!