Yes, I tried that for a while. I was on lithium and Seroquel for about six months, and for the last three months of that I was on lithium (1000mg), lamotrigine (300mg), and Seroquel at the same time. Seroquel seems to be the main med influencing my depression, so I decided to go off lithium and lamotrigine to go a little easier on the kidneys. I didn't notice any benefit or harm from the lamotrigine, but I still hope it can work as a maintenance med even if it isn't enough to get out of this episode.