Thanks, I'll give it a few more days to see what happens. Hopefully the insomnia will subside as well. Last night I slept badly despite taking both Seroquel and lorazepam. Right now there's no change in effects yet. The irritability is gone, I think it was due to the insomnia rather than the bupropion. I'm still really dizzy, though, and even more tired/confused/unable to concentrate than I was before the bupropion. Also, the high blood pressure is a serious side-effect that's definitely not worth it to me if there continue to be no positive effects from this drug. It's weird how much the effects of these meds differ from person to person.