I'm new to this thread. My main problem is depression. However, when I'm having a bad depressive episode, I sometimes get extremely anxious. Those 2 things combined can feel almost intolerable. I take amitriptyline for depression. This morning I was so severely anxious that I called a crisis line. That helped a bit, but not much. I kept breaking down crying while on the phone. Then I got a bright idea. I have some Benadryl on hand. It's for allergy symptoms, and I hardly ever use it. (Makes my mouth too dry.) Well, I took some. Amazingly, it actually helped. I felt different mentally. I even felt different physically. I was so grateful that I found something to ease up how awful I was feeling.