I was taken off ADs when first diagnosed and stayed off for a few years. After my pdoc got to know me and that I didn't respond to mood stabilizers for depression she started using low doses and then higher ones. We went through an large (as in pretty much everything out there before 2009 except old MAOIs and a few tricyclics) number of them before I wound up on Emsam in 2009. I have been on it since without any issues with pooping out or anything. It really helps me.