"The occupancy of dopamine transporter (DAT) by bupropion (300 mg/day) and its metabolites in the human brain as measured by several positron emission tomography (PET) studies is approximately 20%, with a mean occupancy range of about 14 to 26%.[92][93][42] For comparison, the NDRI methylphenidate at therapeutic doses is thought to occupy greater than 50% of DAT sites.[42] In accordance with its low DAT occupancy, no measurable dopamine release in the human brain was detected with bupropion (150 mg/day) in a PET study.[92][93] These findings raise questions about the role of dopamine reuptake inhibition in the pharmacology of bupropion, and suggest that other actions may be responsible for its therapeutic effects.[92][42][93] More research is needed in this area.[94] No data are available on occupancy of the norepinephrine transporter (NET) by bupropion and its metabolites.[92] However, due to the increased exposure of hydroxybupropion over bupropion itself, which has higher affinity to NET than DAT (R,R- has no DAT affinity at all, and S,S- has ~3x higher affinity to NET over DAT), bupropion's overall pharmacological profile in humans may end up making it effectively more of an NRI than a DRI.[88]"

This could be the reason that Wellbutrin can cause mania. My psychiatrist warned me about mania - Like what happened to Job with Wellbutrin.

It would likely happen in a few weeks/months after starting it because the metabolites bind more to norepinephrine. I'll be on 150mg a day which is just an NRI (Not an NDRI). I wonder if the dopamine release from the dextroamphetamine would inhibit some of the norepinephrine.

Kind of scared to take it. Why is it that all of the more therapeutic cathinone/phetamine/phenidates are scheduled substances? Cuz Big Pharma can't make a patent on them. It's ridiculous. That's what the drug war did..