I'm on Emsam which is an MAOI. I couldn't handle other ADs but needed one and so after years of trying various things I went on this. It works well. It doesn't seem to ever cause me to go up although I do lower the dose if my mood is high. It helps depressions in combination with my other meds and I have no complaints. It is very expensive but I get it free through patient assistance. There are some food restrictions except at the bottom dose but it's manageable and there are less restrictions than other MAOIs. I've been on it 12 years and am still happy with it.