It's tough to think about going off a bunch of meds at once. I hear you, it's tough to have to take them, too.

I've often thought of simplifying my medicine regimen.

I usually come back to the conclusion, however, that the meds I am taking now are prescribed for me for a reason, though. And I can discuss this with my pdoc, and he listens to me (I'm glad I have a pdoc that actually listens now). But it's ultimately a matter of how I feel. And I feel pretty good on the meds I'm on now. So I conclude, I should stay on these for now.

My pdoc also seems to explain things really well after I ask him some sort of question regarding what would happen if I went down on a certain medication or the reasons why I should continue taking stuff.

Have you asked your provider directly like why you're taking each medication? Or you could make a list yourself about why you need each med (or don't need for that matter)... Just ideas.