Thanks everyone. It's so strange for me, because on 200 mg, I actually had lost weight. I was down to 113 lbs and 5'6 (woman), but my weight would fluctuate between that and 118...although there was a time where I was about 125, but at one point I was on 600 mg of Seroquel. Since starting Seroquel 300 mg, I went from 115 to 119.5 in a month and a half. I realize I can probably use the weight gain, but I don't want to continue to keep gaining weight. Maybe since it's only a 100 mg increase, it won't make much of a difference, but I'm just trying to monitor the situation.