I would worry about the opiates they gave me after my surgeries and the benzos I'd be prescribed 3 times a day. But neither the doctor or the pharamacy ever said anything and I never had any issue. It did make me super nervous though so I tried to use the opiates as little as possible. I remember after a procedure an ER doctor wanted to prescribe me tramadol but my mom told him no. I didn't even need tylenol after that one. Pain meds scare me though because of possible interactions.