I've also taken both lithium and Depakote. Lithium destroyed my thyroid and now I have to take synthroid. I quit taking it after I became toxic on it. My pdoc failed to check my lithium level at my previous appointment. I ended up in the ER shaking uncontrollably and staring unblinkingly with all the commotion - 30+ doctor's and nurses in my little room and overflowing into the hallway . Depakote also made me gain a lot of weight which I still haven't shed many years later. (Of course part of that gain was from Zyprexa which screwed up my liver.)

Now I take Haldol and Rexulti and Trazodone and seem to be ok on those.