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Old Aug 20, 2022, 11:14 PM
Tart Cherry Jam Tart Cherry Jam is offline
Grand Magnate
 
Member Since: Mar 2021
Location: California
Posts: 3,701
Thank you for the answers! I see that quite a few people have been on these drugs and it alleviates my concerns.

Quote:
Originally Posted by BeyondtheRainbow View Post
Have you been on loxapine? It is something like a between the atypicals and first generation. It has a neat trick that as it breaks down it turns into an anti-depressant so that can boost you if you need that. It also has a big range of dosing which is nice. I didn't have side effects until I developed uncontrollable mouth movements and had to come off it (this is very rare).


I liked it,actually quite a lot, until I couldn't tolerate it. Which is just the way meds are for me. Nothing worked very well until clozapine and you said that's not an option for you which is too bad.
Interesting about Loxapine: Loxapine is extensively metabolized in the liver through aromatic hydroxylation, N-demethylation, or N-oxidation. The metabolite amoxapine is active and marketed as an antidepressant. Loxapine is widely distributed throughout the body, including the central nervous system.
I do not generally need an antidepressant boost: I receive enough of antidepressant action from Gabapentin (somewhat of an idiosyncratic reaction, I know, but I do love my Gabapentin) and in general tend to have more concerns on the manic side of things. But I still would like to try it: maybe it would work just fine without throwing me into mania. I have had episodes of uncontrollable mouth movements (especially tongue movements) a few times when I combined two modern APs, but as soon as I discontinued the combos, the movements stopped. So I would know to discontinue a drug if it starts causing those movements.

I have gone through my records and discovered that at some point in late 2014 I took azaleptin, which was sent to me by my friend oversees. I took it for sleep and it caused tremendous sleepiness, so I discontinued. It did not cause depression. I now see that azaleptin is clozapine, another name for it. So in 2018 I could not tolerate it, but in 2014 I was fine and it just made me very sleepy, but isn't it what I need now? So I will try it again. I have noticed that sometimes the same medication has a different effect. I have tried Topamax several times in my life. I now tolerate it well, taking it for appetite suppression, but in the past it would cause general malaise, or depression, or dizziness. So I realize that it is not all straightforward, it is not that Med A always causes effect or side effect B in the same person. It is more complicated and I should retry Clozapine to see if this time around it might do the trick for me.
Thanks for this!
downandlonely