My experience with Topamax has been that it is a very picky drug when it comes to dosing. Small changes have been consequences for me. I've never gotten above 50 mg and I've had to go back down both times I've made it there because of GI issues. At 25 mg it helps me sleep and seems to work for some mood stabilization. I'm honestly not sure how much it helps now as I'm on a lot of Gabapentin but we're keeping it as is for now.