MD in response to your post in the last checkin thread about Pristiq - in my experience it was as hard to come off as Effexor which was pretty bad. The way I finally got off it was to switch to Prozac which had a long half life and took that for a short time (can’t remember how long - maybe a week?) and then came off that. Because Prozac has such a long half life it’s easy to come off (well some people might have problems but I never have).