Beth,

I take Metforming 500 mg three times a day, not two. I think you can increase it. It is currently a super popular med, at that very dosage, in the community of people looking to extend lifespan and "health span" (not how long in chronological years you live, but how long you remain active and well). While I believe, based on what I have read, that they might be misguided and overly optimistic, the safety profile of metformin has been proven and it is one of the oldest meds on the market. I am not super disciplined about three times a day, but if I stay home and have three meals next to my bottles with meds, I do take it 3X. It has not caused any side effects in me and I take the ER version.