Is there anything better than clozapine? I tried loxapine and my life went to hell. I ended up inpatient. Yet it says it is an excellent alternative to clozapine. One of the reasons I want my clozapine switch was sedation. And I’m on other medicines too. I’m on Depakote ER, Lithium Carbonate, Strattera, Zoloft, and Wellbutrin. I’ve heard that clozapine is the best when nothing else works. I’m still questioning if there is anything out there. And I’d probably have to be hospitalized for them to change it again.